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KMID : 0377519870120010129
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Chung-Ang Journal of Medicine
1987 Volume.12 No. 1 p.129 ~ p.135
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The Change of the Na^(+) K^(+) ATPase Activity and Total Ascorbic Acid Level Following Experimental Spinal Cord Injury in Cats
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Abstract
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Since the discovery of Na+g+ ATPase by Skou in 1957, there have been many convincing reports´ on the decrease of this ferment activity in the tissue of the brain or the spinal cord experimentally injured. ,On the contrary,´ Mac Millan observed the increase of Na+K+ ATPase activity in the rat´s ` brain during 30 min. following experimental ischemia in 1982.
This study is intended to verify the above contradictory results and confirm simultaneously the drop of the total ascorbic acid level (reported by Demopoulos in 1977) in the tissue of the spinal cord experimentally injured.
Following experimental spinal cord injury, the Na+K+ ATPase activity and total ascorbic acid level of spinal cord tissue were measured before and after trauma in 10 cats and before and 5 min. and 30 min. after trauma in another l0 cats. The Na+K+ ATPase activities after trauma increased 21.2/00 in 10 cats .and 14.0%, 11.6% at 5 min. and 30 min. after trauma respectively. The total ascorbic acid levels after trauma reduced 11.7% in 10 cats and 13.1%, 21.8% at 5 min. and 30 min. after trauma respectively.
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